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Is Hepatitis C Curable?
Unfortunately, there is no specific cure for this condition, but a combination of treatments and medicines can lead to hepatitis c being treated. New drugs are making improvements daily and the goal of reaching the point where there is a hep c cure is slowly approaching.
Treatments get better and it is assumed that quite soon, people with this condition will be able to look forward to a future free of the disease.
The goal of every treatment is to fully get rid of the virus in the patient’s body. Patients are considered to be cured if they do not have the virus in the body for a minimum of 6 months after the end of treatment.
The Beginning of Successful Hepatitis C Treatment
The turning point in finding a cure for hepatitis c came when the patients started interferon treatment back in the 1990s. This particular drug is known to boost the immune system which may result in fighting and completely destroying the hepatitis c virus.
What followed was the use of ribavirin, another effective drug in treating hepatitis c patients. Furthermore, these two were combined in a single treatment in order to achieve better results. This combo made the cure rate jump from 5 to 50% by the 2000s.
Some people still choose to avoid treatment since this combo results in serious side effects, such as muscle aches, sleeping problems, nausea, and anxiety. And the duration of their consumption is not really a boost. One must take them for up to 48 weeks for the first results to show.
Later on, in 2011, the FDA also approved boceprevir and telaprevir, otherwise referred to as Victrelis and Incivek. They are making a copy of the virus and stop it in that manner. The combo of the two and the interferon and ribavirin achieved the highest success rates at the time, reaching a percentage of 70%. But this combination was still not as ideal as planned. The addition of two new drugs to the combo increased not only the cure rate but the side effects too.
The FDA approved four new drugs in 2013 and 2014: ledipasvir-sofosbuvir, ombitasvir-paritaprevir-dasabuvir-ritonavir, simeprevir, and sofosbuvir. These are also referred to as Harvoni, Viekira Pak, Olysio and Sovaldi. The four are considered the new standard in treating hepatitis c. The treatment depends on the type of hepatitis C virus (genotype 1, 2,3,4,5 or 6).
Lepidasvir-sofosbuvir is used to treat the hepatitis virus of genotype 1. It can be taken without ribavirin and interferon.
Treating Acute Hepatitis C
If the hepatitis c infection is diagnosed in an early staged, the treatment of this acute hepatitis c may be delayed. A doctor may decide to perform a blood test in a couple of months to see if the body has managed to fight off the virus by itself. If the virus remains after a few months, this is known as chronic hepatitis and a treatment must follow.
Treating Hepatitis C
Treatment of hepatitis c does not involve hep c cure, but it may involve:
- Lifestyle changes
A few lifestyle changes may help prevent further liver damage and reduce the risk of infection spreading in the body.
- Medications combo
A combination of a minimum of 2 medications can increase the chances of success in fighting the virus. The duration of medications treatment lasts from 12 to 48 weeks. This depends on the medicine combo and the version of the hepatitis c.
The 6 Genotypes of the Hepatitis C Virus
A blood test during treatment is a must. These are used to show if the medication is working. If the tests result in minor improvements in fighting the virus, another treatment may be proposed ant this one can be stopped.
If a patient wants to cure hepatitis c, there are a couple of things that must be done to limit liver damage and prevent the infection from spreading. These may include:
- Eating a healthy diet
- Regular exercise
- Cutting out alcohol completely or limiting the intake to a minimum
- Quitting smoking
- Not sharing needles, syringes, toothbrushes, and razors with anyone
Can Hepatitis C Be Cured in the near future?
The medical advancements reach the time where one pill a day with minor side effects becomes possible. The new interferon-free drugs are expected to come and be approved really soon.
- People with chronic HCV genotype 1 are prescribed the Viekira Pak multi-pill. The purpose of this treatment is to prohibit the hepatitis c growth. The recommended dosage is 2 ombitasvir, paritaprevir, ritonavir tablets in the morning and one dasabuvir in the morning and the evening. This treatment lasts for a minimum of 12 weeks and has proved to result with a 91- 100 cure rate.
- Another combination is simeprevir with ribavirin and interferon. This combination is used to clear up the virus in 80% of patients that consume it.
- Sofosbuvir can also be used without interferon. This applies to cases of patients suffering from some other types of hepatitis c. This treatment comes in the form of a pill that is taken once a day for a period of 12 weeks. The number of people being cured of it reaches 90%.
- In 2014, the FDA also granted Olysio to be combined with Sovaldi without adding interferon or ribavirin. This is a treatment for genotype 1 hepatitis C patients.
- In 2015, the FDA approved the combo of ombitasvir, paritaprevir, ritonavir and ribavirin for the treatment of hepatitis C of genotype 4. This is the first option for patients who are infected with genotype 4 that does not include interferon. The cure rates are as high as 100%.
- In the same year, the FDA approved daclatasvir as a treatment for genotype 3 infections. This is taken in combination with Sovaldi to increase the cure rates to 98%.
- This year, elbasvir and grazoprevir were approved to be used in combination without ribavirin. This combo is used to treat genotype 4 and 1. It is a single tablet drug that joins Viekira Pak and Harvoni in genotype 1 treatments, with the exclusion of interferon. The cure rates reach 94%-97% for genotype 1 and 100% cure rates for genotype 4.
- Pegylated interferon is taken in the form of a weekly injection and the patient may be trained to inject himself at home. The treatment usually lasts for up to 48 weeks, depending on the circumstances.
- Ribavirin is available in the form of tablets, capsules or oral solution. It is usually consumed twice daily in combination with food. It needs to be taken for 48 weeks.
The Effectiveness of Treatment
The effectiveness of hepatitis c treatment depends on the existing virus type. Genotype 1 was more challenging in the past when less than half of the people diagnosed with it could be cured. The new advances in treatment available increased the chances of hepatitis c cure greatly and the cure rate now reached higher than 90%. This is now higher than the chances of curing the other hepatitis c genotypes.
The treatment for genotype 3 most commonly involves standard treatments of pegylated interferon and ribavirin. The cure rate here reaches 70-80% of the patients taking this cure.
Having been treated by the virus does not provide you with a guarantee. Patients who are successfully treated from hepatitis c, are not immune to the infection and can be infected again.
If the treatment does not prove to be effective, it may either be repeated, extended or replaced with another that uses different medication combinations.
Side Effects of Treatment
Side effects of the therapies for hepatitis c are quite common, especially if the treatment involves interferon. The new advanced tablet treatments have fewer side effects, some even so minor that people feel almost unaffected by them.
In treatments that involve interferon, the following side effects are to be expected:
- Flu symptoms such as fatigue and extreme tiredness
- Reduced red blood cells number
- Itchy skin
- Felling of sickness
- Sleeping problems and insomnia
- Loss of appetite
- Excessive weight loss
The medications for hepatitis c can also cause unpredictable and unexpected reactions if taken with other remedies or medicines. Therefore, one must always inform the doctor of the medications they are taking in order for the doctor to find the right treatment to use to cure hepatitis C.
Side effects are also known to improve with time. This happens as the body gets used to the medications. In cases where the side effects are too troublesome, some changes in treatment must be made.
If the side effects are not too difficult to handle, one must continue taking the medications as instructed. Sure, this can be challenging but it must be in order to be effective. Missing doses for the purpose of avoiding side effects may worsen the condition and reduce the chances of being cured.
Hepatitis C Treatment during Pregnancy
The medications that are usually used to cure hepatitis c can be harmful to the child a woman is carrying. Some drugs, such as ribavirin, are not used during pregnancy. In most cases of pregnant women being diagnosed with hepatitis c, the treatment is delayed until the giving of birth. Otherwise, the advice of the doctors is to use contraception throughout the treatment and perform regular pregnancy tests.
When it comes to men taking ribavirin, it is not recommended to have sex with a pregnant woman without a condom. Even in cases where the partner is not pregnant, contraception should always be used in the duration of the treatment. The partner may need to have regular pregnancy tests.
Decision against Treatment
As previously stated, some people who suffer from chronic hepatitis C decide not to go with treatment. The reasons may be the following:
- They do not experience any symptoms of the disease
- They are willing to live with the risk of cirrhosis
- They do not find the treatment a good option because of the side effects it can cause
Every patient is advised on this, but the final decision is always left to them. If a patient decides on not having treatment, he can always change the decision and ask to be treated later.
Serious chronic hepatitis c complications may lead to the sole option for a cure being liver transplantation. During this procedure, the surgeon replaces the damaged liver with a healthy one. Most of these healthy lives come from deceased donors, but people now have the chance to donate a portion of their livers too.
A liver transplant does not mean that the patient is cured of hepatitis C. The infection is very likely to return in most cases, requiring additional antiviral medication treatment. This is used to prevent damage to the healthy transplanted liver.
There are several studies nowadays that have demonstrated that a few antiviral regimens of direct-acting medication are actually effective at curing hepatitis C after a transplant. Treatment with antiviral can also prove to be effective in some patients prior to the start of the liver transplantation surgery.
Vaccines for Hepatitis C
Even though there is no cure for hepatitis c, there are certain vaccines that may be recommended as a treatment type. These vaccines are only available for hepatitis A and B viruses, but can also help cure the hepatitis C virus.
Hepatitis c is a commonly spread virus and there are many people suffering from this disease today. However, the medical advances move fast and new medications for treating this disease are approved every year. With the advanced medication of nowadays and the speed of progress in treatment, a cure for hepatitis c is probably soon to be found.